Our research aims at understanding biomolecular interactions of proteins and polypeptides involved in biological and disease-associated processes via chemistry and at developing novel molecular strategies, compounds, and chemical tools to intervene with these processes.
We are especially interested in understanding biomolecular recognition, biological function, and molecular processes linked to disease associated protein aggregation and cell degeneration, using protein(peptide) chemical design and synthesis strategies and in designing peptide-based compounds as agonists, antagonists, modulators, competitors, or inhibitors of the above processes and related biological or disease associated effects.
Current research activities focus on:
-- understanding protein misfolding, protein/protein interactions, self-assembly, amyloidogenesis, and gain-of-cell-toxicity molecular events underlying cell degeneration and pathogenesis of the protein aggregation diseases Alzheimer`s disease (AD) and type II diabetes (T2D) and
-- designing/developing novel peptide-based molecular strategies to interfere with protein misfolding, aggregation, and cell degeneration and to generate therapeutic compounds and non-invasive diagnostic tools in AD and T2D.